抗利尿激素对肾内微球分布的影响。

G Fejes-Tóth, T Zahajszky, J Filep
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引用次数: 0

摘要

本研究旨在用微球技术重新研究抗利尿激素对麻醉大鼠肾内血流分布的影响。给药3、6或60 mU/kg/h的精氨酸-加压素(VP)伴有剂量依赖性抗利尿。肾小球滤过率仅在剂量水平为60 mU/kg/h时增加,较低剂量对肾小球滤过率无显著影响。肾总血流量没有受到任何剂量VP的显著影响。两种小剂量VP均未引起皮质内微球分布的变化,但当VP浓度为60 mU/kg/h时,皮质外血流与皮质内血流之比显著降低。结果表明,生理剂量的VP不会改变肾内血流的分布,表明VP的抗利尿作用与肾血流动力学的变化无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of antidiuretic hormone on intrarenal microsphere distribution.

The aim of the present study was to reexamine the effect of antidiuretic hormone on intrarenal blood flow distribution by the microsphere technique in anaesthetized rats. The administration of 3, 6 or 60 mU/kg/h of arginine-vasopressin (VP) was accompanied by a dose-dependent antidiuresis. Glomerular filtration rate increased only at the dose level of 60 mU/kg/h and was not significantly altered by the lower doses. Total renal blood flow was not significantly influenced by any of the doses of VP. The two small doses caused no change in intracortical microsphere distribution but there was a significant decrease in the ratio of outer to inner cortical blood flow when 60 mU/kg/h of VP was infused. The results indicate that physiological doses of VP do not alter the distribution of intrarenal blood flow and show that the antidiuretic effect of VP is independent of changes in renal haemodynamics.

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