{"title":"小鼠口服免疫后肺部出现流感特异性抗体。","authors":"K C Bergmann, R H Waldman","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>After nasal, oral and rectal immunization of Balb/c and CF 1 mice with influenza virus (A/PR/8/34, HON 1) specific antibodies (hemagglutination inhibition test) occur in serum and in the lung of mice, detectable in lung lavage fluids. The nasal route of immunization leads to slightly better local antibody production, but the oral route is a promising route, and should be tried in humans.</p>","PeriodicalId":76107,"journal":{"name":"Le Poumon et le coeur","volume":"38 5","pages":"289-92"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Occurrence of influenza specific antibodies in the lung after oral immunization in mice.\",\"authors\":\"K C Bergmann, R H Waldman\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>After nasal, oral and rectal immunization of Balb/c and CF 1 mice with influenza virus (A/PR/8/34, HON 1) specific antibodies (hemagglutination inhibition test) occur in serum and in the lung of mice, detectable in lung lavage fluids. The nasal route of immunization leads to slightly better local antibody production, but the oral route is a promising route, and should be tried in humans.</p>\",\"PeriodicalId\":76107,\"journal\":{\"name\":\"Le Poumon et le coeur\",\"volume\":\"38 5\",\"pages\":\"289-92\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Le Poumon et le coeur\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Le Poumon et le coeur","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
用流感病毒(A/PR/8/34, HON 1)特异性抗体(血凝抑制试验)经鼻、口、直肠免疫Balb/c和CF 1小鼠后，小鼠血清和肺中出现特异性抗体，肺灌洗液中可检测到特异性抗体。鼻腔免疫途径导致局部抗体产生稍好，但口服途径是一种有前途的途径，应在人体中进行试验。
Occurrence of influenza specific antibodies in the lung after oral immunization in mice.
After nasal, oral and rectal immunization of Balb/c and CF 1 mice with influenza virus (A/PR/8/34, HON 1) specific antibodies (hemagglutination inhibition test) occur in serum and in the lung of mice, detectable in lung lavage fluids. The nasal route of immunization leads to slightly better local antibody production, but the oral route is a promising route, and should be tried in humans.
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