大鼠后脑n -乙酰5 -羟色胺(NAS)的免疫组织学定位

Olga M. Pulido , Gregory M. Brown , Lee J. Grota
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引用次数: 6

摘要

1.1. 采用一种特异性抗NAS抗体和荧光素标记的第二抗体,研究了免疫反应性NAS (INAS)在大鼠后脑的地形分布。在小脑颗粒层、第五脑神经脊髓束和脑桥网状结构中证实了INAS的阳性鉴定。在浦肯野细胞的神经元胞体和突起、所有小脑核、蓝斑座和其他脑干区域也发现了INAS。发现INAS的分布模式与血清素和褪黑素不同。在小脑和蓝斑等区域发现了含有INAS和NE的结构重叠,这表明这些物质在某些区域之间可能存在功能联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Localization of N-acetylserotonin (NAS) in the rat hindbrain by immunohistology

  • 1.

    1. A specific anti-NAS antibody and fluorescein-labelled second antibody were employed to investigate the topographic distribution of immunoreactive NAS (INAS) in the hindbrain of the rat.

  • 2.

    2. Positive identification of INAS was confirmed in the granular layer of the cerebellum, the spinal tract of the fifth cranial nerve and the pontine reticular formation.

  • 3.

    3. INAS was also identified in neuronal cell bodies and processes of Purkinje cells, all cerebellar nuclei, the locus coeruleus and other brain stem regions.

  • 4.

    4. The pattern of INAS distribution was found to be different from that of serotonin and melatonin.

  • 5.

    5. Overlap of INAS- and NE- containing structures was identified in areas such as cerebellum and locus coeruleus, suggesting the possibility of a functional connection between these substances in some regions.

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