Ashim C. Roy, P.Ganesan Adaikan, Sultan M.M. Karim
{"title":"静脉输注OKY-1581(钠-(E)-3-[4-(3-吡啶基甲基)苯基]-2-甲基丙烯酸酯)对麻醉狒狒循环血栓素A2和前列环素水平的影响","authors":"Ashim C. Roy, P.Ganesan Adaikan, Sultan M.M. Karim","doi":"10.1016/0161-4630(81)90104-X","DOIUrl":null,"url":null,"abstract":"<div><p>OKY-1581, a known inhibitor of thromboxane biosynthesis, was infused intravenously in six healthy baboons anaesthetized with pentobarbitone sodium. Systemic blood pressure and heart rate were continuously recorded and the levels of plasma thromboxane B<sub>2</sub> and 6-keto PGF<sub>1α</sub> were determined in samples taken before, during and after the infusion of OKY-1581. Following the infusion of OKY-1581 plasma level of TXB<sub>2</sub> decreased and 6-keto PGF<sub>1α</sub> level increased in most animals. However, these changes were not consistent or dose-related and no significant effect was seen in some animals.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 3","pages":"Pages 253-259"},"PeriodicalIF":0.0000,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90104-X","citationCount":"6","resultStr":"{\"title\":\"Effect of intravenous infusion of OKY-1581 (Sodium-(E)-3-[4-(3-pyridylmethyl)phenyl]-2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon\",\"authors\":\"Ashim C. Roy, P.Ganesan Adaikan, Sultan M.M. Karim\",\"doi\":\"10.1016/0161-4630(81)90104-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>OKY-1581, a known inhibitor of thromboxane biosynthesis, was infused intravenously in six healthy baboons anaesthetized with pentobarbitone sodium. Systemic blood pressure and heart rate were continuously recorded and the levels of plasma thromboxane B<sub>2</sub> and 6-keto PGF<sub>1α</sub> were determined in samples taken before, during and after the infusion of OKY-1581. Following the infusion of OKY-1581 plasma level of TXB<sub>2</sub> decreased and 6-keto PGF<sub>1α</sub> level increased in most animals. However, these changes were not consistent or dose-related and no significant effect was seen in some animals.</p></div>\",\"PeriodicalId\":76381,\"journal\":{\"name\":\"Prostaglandins and medicine\",\"volume\":\"7 3\",\"pages\":\"Pages 253-259\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-4630(81)90104-X\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/016146308190104X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/016146308190104X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of intravenous infusion of OKY-1581 (Sodium-(E)-3-[4-(3-pyridylmethyl)phenyl]-2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon
OKY-1581, a known inhibitor of thromboxane biosynthesis, was infused intravenously in six healthy baboons anaesthetized with pentobarbitone sodium. Systemic blood pressure and heart rate were continuously recorded and the levels of plasma thromboxane B2 and 6-keto PGF1α were determined in samples taken before, during and after the infusion of OKY-1581. Following the infusion of OKY-1581 plasma level of TXB2 decreased and 6-keto PGF1α level increased in most animals. However, these changes were not consistent or dose-related and no significant effect was seen in some animals.
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