Jambur Ananth , John C. Pecknold , Nancy Van Den Steen , Frank Engelsmann
{"title":"氯丙帕明与阿米替林治疗强迫神经症的双盲比较研究","authors":"Jambur Ananth , John C. Pecknold , Nancy Van Den Steen , Frank Engelsmann","doi":"10.1016/0364-7722(81)90077-1","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis (OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.</p></span></li><li><span>2.</span><span><p>2. Clomipramine but not amitriptyline produced statistically significant improvement in the obsessive symptoms, depression and anxiety.</p></span></li><li><span>3.</span><span><p>3. The lack of significant effect of amitriptyline on anxiety and depression may be due to its inability to improve the primary obsessive symptoms.</p></span></li><li><span>4.</span><span><p>4. No serious adverse effects were encountered in either drug group.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90077-1","citationCount":"137","resultStr":"{\"title\":\"Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis\",\"authors\":\"Jambur Ananth , John C. Pecknold , Nancy Van Den Steen , Frank Engelsmann\",\"doi\":\"10.1016/0364-7722(81)90077-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis (OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.</p></span></li><li><span>2.</span><span><p>2. Clomipramine but not amitriptyline produced statistically significant improvement in the obsessive symptoms, depression and anxiety.</p></span></li><li><span>3.</span><span><p>3. The lack of significant effect of amitriptyline on anxiety and depression may be due to its inability to improve the primary obsessive symptoms.</p></span></li><li><span>4.</span><span><p>4. No serious adverse effects were encountered in either drug group.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90077-1\",\"citationCount\":\"137\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900771\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900771","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis
1.
1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis (OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.
2.
2. Clomipramine but not amitriptyline produced statistically significant improvement in the obsessive symptoms, depression and anxiety.
3.
3. The lack of significant effect of amitriptyline on anxiety and depression may be due to its inability to improve the primary obsessive symptoms.
4.
4. No serious adverse effects were encountered in either drug group.
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