PGF2 α刺激离体灌注大鼠心脏中PGE2和PGI2的释放。

Advances in prostaglandin and thromboxane research Pub Date : 1980-01-01

E A de Deckere, F ten Hoor

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摘要

在离体灌注大鼠心脏中研究前列腺素F2 α对PGI2和PGE2释放的影响。PGF2 α浓度为1.7 nmol l -1或更高时，PGI2和PGE2 α的释放增加。PGF2 α灌注3 ~ 4min后，PGI2释放量最高。这一现象可能具有生理意义，并可能解释PGF2 α对血管阻力的可变影响。

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PGF2 alpha stimulates release of PGE2 and PGI2 in the isolated perfused rat heart.

The effect of prostaglandin F2 alpha on the release of PGI2 and PGE2 was investigated in isolated perfused rat heart. PGF2 alpha at concentrations of 1.7 nmoles liter-1 or higher increased the release of PGI2 and PGE2 alpha. The release of PGI2 was highest after 3 to 4 min of perfusion with PGF2 alpha. This phenomenon may be of physiological significance and might explain the observed variable effects of PGF2 alpha on vascular resistance.

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Advances in prostaglandin and thromboxane research

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