促瘤剂诱导淋巴细胞有丝分裂因子。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

S K Sundar, D V Ablashi, P H Levine, W C Wallen, G R Armstrong

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引用次数: 0

摘要

促瘤剂12- o -十四烷酚13-醋酸酯(TPA)处理后的人外周血单核细胞释放出可溶性淋巴细胞有丝分裂因子(MF)。发现MF是一种能够在40-46小时内在正常人类淋巴细胞中引起增殖反应的蛋白质。早在TPA处理后12小时，在培养上清液中检测到MF，并在48小时达到最大值。MF的生化特性正在积极研究中。

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Tumor promoting agent induces lymphocyte mitogenic factor.

Human peripheral mononuclear cells treated with tumor promoting agent, 12-O-tetradecanoyl phorbol 13-acetate (TPA), released a soluble lymphocyte mitogenic factor (MF). The MF was found to be a protein capable of eliciting a proliferative response in normal human lymphocytes within 40-46 hours. The MF was detected in the culture supernatant fluid as early as 12 hours after TPA treatment and reached maximum at 48 hours. The biochemical characterization of MF is under active investigation.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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