粘接剂在大鼠和家兔横向骨折修复中的实验应用。

F J Papatheofanis, R D Ray
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引用次数: 10

摘要

在本初步研究中,探讨了乙基和异丁基2-氰基丙烯酸酯、预聚合的藤瓶水泥和纤维蛋白胶固定骨折的可行性。当脂质存在于由2-氰基丙烯酸烷基酯连接的表面时,不能获得足够的内聚强度。将经高浓度纤维蛋白原溶液浸泡的氧化再生纤维素纱布插入部分中空的骨折端,以阻止髓管渗出血液的流动。用无水醚海绵去除骨表面残留的脂质。将移位的骨折端对齐,并在骨折线周围固定窄骨条,形成桶状骨折。x线图显示8个大鼠(股骨)和7个兔(胫骨)模型的横向(中轴)骨折成功复位。在一些病例中,使用铸型作为辅助固定。使用乙基和2-氰基丙烯酸酯异丁基,复位骨折分别保持在稳定位置长达5天和6天。建议对2-氰基丙烯酸酯进行进一步研究。通过使用标准化的手术方法在体内测试未来粘接剂的有效性,将有助于对结果进行一致的解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experimental use of adhesives in the repair of transverse fractures of the rat and rabbit.

In this preliminary study, the feasibility of fixing fractured bones was explored using the ethyl and isobutyl 2-cyano-acrylates, prepolymerized barnacle cement, and fibrin glue. Adequate cohesive strength cannot be obtained when lipids are present on the surface to be joined by alkyl 2-cyanoacrylates. Oxidized regenerated cellulose gauze soaked in a highly concentrated fibrinogen solution was inserted into the partially hollowed fracture ends to arrest the flow of oozing blood from the medullary canal. Anhydrous ether was used to sponge off any residual lipid from the bone surfaces. The displaced fracture ends were aligned and narrow strips of bone were secured around the fracture line resulting in a barrel stave arrangement. Roentgenograms indicated successful reduction of transverse (midshaft) fractures in eight rat (femur) and seven rabbit (tibia) models. In some cases, casts were used as supplementary fixation. Using the ethyl and isobutyl 2-cyanoacrylates, reduced fractures were maintained in a stable position for up to five and six days, respectively. Further study of the 2-cyanoacrylates is recommended. By using a standardized surgical method for testing the usefulness of future adhesives in vivo, consistent interpretation of results will be facilitated.

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