{"title":"慢性美曲霉嗪中毒豚鼠胃黏膜糖蛋白代谢的研究。","authors":"K Zwierz, J Tomaszewski, A Rózański, S Kreczko","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Forty male guinea pigs weighting 400--600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed in the gastric mucosa a significant decrease in glucosamine isomerase activity and a significant increased in beta-glucosidase and beta-galactosidase activity. The results suggest that the biosynthesis of the sugar moiety of glycoproteins is depressed, the degradation of glycoproteins is stimulated by metribuzin.</p>","PeriodicalId":7056,"journal":{"name":"Acta biologica Academiae Scientiarum Hungaricae","volume":"32 1","pages":"69-73"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glycoprotein metabolism in the guinea-pig gastric mucosa in chronic metribuzin poisoning.\",\"authors\":\"K Zwierz, J Tomaszewski, A Rózański, S Kreczko\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Forty male guinea pigs weighting 400--600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed in the gastric mucosa a significant decrease in glucosamine isomerase activity and a significant increased in beta-glucosidase and beta-galactosidase activity. The results suggest that the biosynthesis of the sugar moiety of glycoproteins is depressed, the degradation of glycoproteins is stimulated by metribuzin.</p>\",\"PeriodicalId\":7056,\"journal\":{\"name\":\"Acta biologica Academiae Scientiarum Hungaricae\",\"volume\":\"32 1\",\"pages\":\"69-73\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta biologica Academiae Scientiarum Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta biologica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Glycoprotein metabolism in the guinea-pig gastric mucosa in chronic metribuzin poisoning.
Forty male guinea pigs weighting 400--600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed in the gastric mucosa a significant decrease in glucosamine isomerase activity and a significant increased in beta-glucosidase and beta-galactosidase activity. The results suggest that the biosynthesis of the sugar moiety of glycoproteins is depressed, the degradation of glycoproteins is stimulated by metribuzin.
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