[2-甲氧基乙醇及其衍生物对大鼠的免疫调节作用]。

Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles Pub Date : 1980-09-15

F Delbarre, A Kahan, A de Géry, K Konrad

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引用次数: 0

摘要

作者测定了甲氧基-2乙醇及其衍生物或类似物对大鼠佐剂性关节炎的影响，以及甲氧基-2乙醇对大鼠抗原刺激的体液反应的活性。在13个被试衍生物中，只有甲氧基-2乙醇、1,2-二甲氧基乙烷和1-甲氧基-2乙氧基乙烷对佐剂性关节炎有抑制作用。甲氧基-2乙醇对免疫刺激后的抗体产生有显著抑制作用，对皮肤移植排斥反应有显著影响。尽管这些结果令人感兴趣，但甲氧基-2乙醇的毒性将是治疗用途的限制因素。

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[Immunomodulating action of 2-methoxyethanol and homologous derivatives in rats].

The authors have measured the effects of methoxy-2 ethanol and derivatives or analogs on adjuvant arthritis in Rat, and the activity of methoxy-2 ethanol on humoral responsiveness to antigenic stimuli in Rat. Only methoxy-2 ethanol,1,2-dimethoxyethane and 1-methoxy 2 ethoxy ethane out of 13 tested derivatives, have an inhibitory activity on adjuvant arthritis. Methoxy-2 ethanol induces a significant depression of antibody production after immune stimuli and a significant effect on rejection of the skin graft. Although these results are of interest, toxicity of methoxy-2 ethanol will be a limiting factor for therapeutic use.

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Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles

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