环孢素A治疗兔血清病并发皮质梗死的研究。

Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Pub Date : 1983-01-01

G H Neild, K Ivory, D G Williams

{"title":"环孢素A治疗兔血清病并发皮质梗死的研究。","authors":"G H Neild, K Ivory, D G Williams","doi":"","DOIUrl":null,"url":null,"abstract":"Rabbits given acute serum sickness (ASS) and treated with Cyclosporin A (CyA) developed glomerular capillary thrombosis and cortical infarction. These lesions were associated with severe endothelial injury and platelet-fibrin-leucocyte thrombi. They were not seen in untreated rabbits with ASS, nor in normal rabbits given CyA alone in equivalent doses. A similar renal lesion has been reported in patients receiving CyA following bone marrow transplantation.","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"662-8"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cortical infarction in rabbits with serum sickness following Cyclosporin A therapy.\",\"authors\":\"G H Neild, K Ivory, D G Williams\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Rabbits given acute serum sickness (ASS) and treated with Cyclosporin A (CyA) developed glomerular capillary thrombosis and cortical infarction. These lesions were associated with severe endothelial injury and platelet-fibrin-leucocyte thrombi. They were not seen in untreated rabbits with ASS, nor in normal rabbits given CyA alone in equivalent doses. A similar renal lesion has been reported in patients receiving CyA following bone marrow transplantation.\",\"PeriodicalId\":76354,\"journal\":{\"name\":\"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association\",\"volume\":\"20 \",\"pages\":\"662-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

急性血清病(acute serum sickness, ASS)和环孢素A (Cyclosporin A, CyA)治疗的家兔出现肾小球毛细血管血栓和皮质梗死。这些病变与严重的内皮损伤和血小板-纤维蛋白-白细胞血栓有关。它们在未治疗的ASS家兔中未见，在单独给予等量CyA的正常家兔中也未见。在骨髓移植后接受CyA的患者中也有类似的肾脏病变的报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Cortical infarction in rabbits with serum sickness following Cyclosporin A therapy.

Rabbits given acute serum sickness (ASS) and treated with Cyclosporin A (CyA) developed glomerular capillary thrombosis and cortical infarction. These lesions were associated with severe endothelial injury and platelet-fibrin-leucocyte thrombi. They were not seen in untreated rabbits with ASS, nor in normal rabbits given CyA alone in equivalent doses. A similar renal lesion has been reported in patients receiving CyA following bone marrow transplantation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association

自引率

0.00%

发文量