R Labia, M Guionie, A Morand, M Barthélémy, J C Doré
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引用次数: 0
摘要
n -甲酰基硫霉素(MK-0787)不受β -内酰胺酶水解的影响。然而，这种化合物确实对tem型青霉素酶、头孢菌素酶和其他一些β -内酰胺酶有一定的亲和力。令人惊讶的是，没有发现carb型青霉素酶的亲和力。由此得到的亲和常数Ki和Km的结果提交了统计分析处理，即对应分析和层次上升分类。这证实了MK-0787对β -内酰胺酶表现出不寻常的行为。
[Affinity of N-formimidoyl-thienamycin (MK-0787) for beta-lactamases, analysis by a statistical method: correspondence analysis].
N-formimidoyl-thienamycin (MK-0787) is not subject to beta-lactamase hydrolysis. Nevertheless, this compound does show some affinity for the TEM-type penicillinases, cephalosporinases and a few other beta-lactamases. Surprisingly no affinity was found for the penicillinases of the CARB-type. The results thus obtained for affinity constants Ki and Km were submitted to a statistical analysis treatment, i.e. correspondence analysis and hierarchic ascendent classification. This confirms the fact that MK-0787 presents an unusual behaviour towards beta-lactamases.
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