G Uhlenbruck, U van Meensel-Maene, F G Hanisch, C Dienst
{"title":"正常人精浆中Ca 19-9肿瘤标志物的意外出现。","authors":"G Uhlenbruck, U van Meensel-Maene, F G Hanisch, C Dienst","doi":"10.1515/bchm2.1984.365.1.613","DOIUrl":null,"url":null,"abstract":"<p><p>A monoclonal antibody with anti-sialyl-lacto-N-fucopentaose II specificity, originally thought to be a specific tumor marker in pancreas- and gastrointestinal tumors, reacts strongly with fucose-rich glycoproteins from human seminal plasma obtained by phenol/saline extraction. They are presumed to come from the prostatic gland secretion. Because of the specificity of this monoclonal antibody it can be deduced that the sialyl-Lea-sequence: N-acetyl-alpha-neuraminyl-(2----3)-beta-D-galactopyranosyl-(1--- -3)-[alpha-L-fucopyranosyl-(1----4)]-2-acetamido-2-deoxy-beta-D-gluco pyranosyl-(1----3)-D-galactopyranosyl is present on these glycoproteins. This is also supported by our carbohydrate analysis.</p>","PeriodicalId":13015,"journal":{"name":"Hoppe-Seyler's Zeitschrift fur physiologische Chemie","volume":"365 6","pages":"613-7"},"PeriodicalIF":0.0000,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bchm2.1984.365.1.613","citationCount":"27","resultStr":"{\"title\":\"Unexpected occurrence of the Ca 19-9 tumor marker in normal human seminal plasma.\",\"authors\":\"G Uhlenbruck, U van Meensel-Maene, F G Hanisch, C Dienst\",\"doi\":\"10.1515/bchm2.1984.365.1.613\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A monoclonal antibody with anti-sialyl-lacto-N-fucopentaose II specificity, originally thought to be a specific tumor marker in pancreas- and gastrointestinal tumors, reacts strongly with fucose-rich glycoproteins from human seminal plasma obtained by phenol/saline extraction. They are presumed to come from the prostatic gland secretion. Because of the specificity of this monoclonal antibody it can be deduced that the sialyl-Lea-sequence: N-acetyl-alpha-neuraminyl-(2----3)-beta-D-galactopyranosyl-(1--- -3)-[alpha-L-fucopyranosyl-(1----4)]-2-acetamido-2-deoxy-beta-D-gluco pyranosyl-(1----3)-D-galactopyranosyl is present on these glycoproteins. This is also supported by our carbohydrate analysis.</p>\",\"PeriodicalId\":13015,\"journal\":{\"name\":\"Hoppe-Seyler's Zeitschrift fur physiologische Chemie\",\"volume\":\"365 6\",\"pages\":\"613-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1515/bchm2.1984.365.1.613\",\"citationCount\":\"27\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hoppe-Seyler's Zeitschrift fur physiologische Chemie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/bchm2.1984.365.1.613\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hoppe-Seyler's Zeitschrift fur physiologische Chemie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/bchm2.1984.365.1.613","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Unexpected occurrence of the Ca 19-9 tumor marker in normal human seminal plasma.
A monoclonal antibody with anti-sialyl-lacto-N-fucopentaose II specificity, originally thought to be a specific tumor marker in pancreas- and gastrointestinal tumors, reacts strongly with fucose-rich glycoproteins from human seminal plasma obtained by phenol/saline extraction. They are presumed to come from the prostatic gland secretion. Because of the specificity of this monoclonal antibody it can be deduced that the sialyl-Lea-sequence: N-acetyl-alpha-neuraminyl-(2----3)-beta-D-galactopyranosyl-(1--- -3)-[alpha-L-fucopyranosyl-(1----4)]-2-acetamido-2-deoxy-beta-D-gluco pyranosyl-(1----3)-D-galactopyranosyl is present on these glycoproteins. This is also supported by our carbohydrate analysis.
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