乙醇对胆红素和胆汁酸分泌的急性和慢性影响。

Substance and alcohol actions/misuse Pub Date : 1984-01-01
G Vendemiale, C S Lieber
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引用次数: 0

摘要

急性用乙醇处理的大鼠胆红素分泌和血清胆红素水平显著增加(与生理盐水处理的对照组相比);胆汁酸分泌无明显差异。在长期喂食乙醇(总能量的36%,持续4-6周)的大鼠中,与成对喂食的对照组相比,胆红素和胆汁酸的分泌显著增加。在实验时,我们在血液中存在或不存在酒精的情况下观察到这种效应。然而,血液中乙醇的存在导致胆红素和血清胆红素水平升高。胆汁酸分泌的增加涉及选择性二羟基胆汁酸(而不是三羟基胆汁酸)。由于非共轭胆红素分泌的增加有利于色素胆结石的形成,因此可以假设乙醇通过增强胆道色素的分泌来促进胆石症的发病机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute and chronic effects of ethanol on biliary secretion of bilirubin and bile acids.

Rats treated acutely with ethanol showed a significant increase in biliary bilirubin secretion and in serum bilirubin levels (compared to saline treated controls); no difference was found in bile acid secretion. In rats fed ethanol chronically (36% of total energy for 4-6 weeks) there was a significant increase in the secretion of bilirubin and bile acids when compared to pair fed controls. We observed this effect either in the presence or in the absence of alcohol in the blood at the time of the experiment. The presence of ethanol in the blood, however, resulted in higher biliary and serum bilirubin levels. The increase in bile acid secretion involved selectively di- (but not tri-) hydroxy bile acids. Since increased secretion of unconjugated bilirubin favors pigment gallstones formation, it can be postulated that ethanol contributes to the pathogenesis of cholelithiasis by enhancing the biliary secretion of the pigment.

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