x射线照射下DNA中8-羟基鸟嘌呤残基的形成。

Gan Pub Date : 1984-12-01

H Kasai, H Tanooka, S Nishimura

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引用次数: 0

摘要

在水溶液中经x射线辐照的DNA中发现了一种新的电离辐射诱导的DNA碱基损伤，即8-羟基鸟嘌呤的形成。这种变化的程度随着x射线剂量的增加而线性增加，直至40克拉。当在DNA溶液中加入OH自由基清除剂乙醇时，氢化作用几乎完全被抑制，这表明反应是通过OH自由基的形成进行的。

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Formation of 8-hydroxyguanine residues in DNA by X-irradiation.

A new type of ionizing radiation-induced DNA base damage, 8-hydroxyguanine formation, was found in DNA that had been irradiated by X-rays in aqueous solution. The extent of this modification linearly increased with increase in the X-ray dose up to 40 krad. When an OH radical scavenger, ethanol, was added to the DNA solution, the hydroxylation was inhibited almost completely, suggesting that the reaction proceeds via the formation of OH radicals.

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Gan

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