T Horiuchi, H Fujiki, M Suganuma, H Hakii, M Nakayasu, Y Hitotsuyanagi, N Aimi, S Sakai, Y Endo, K Shudo
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引用次数: 0
摘要
三种橄榄素，A, B和C(分离自橄榄oreticuli链霉)，它们是o甲基化的远杀菌素B异构体，被发现具有生物活性。第四种橄榄素D具有一个游离羟基，与四种远杀素B异构体中的一种相同，远杀素B-4 (Hirata的远杀素B)具有生物活性。这些发现表明，远杀菌素B异构体的游离初级羟基是活性所必需的。还研究了脱氧- o -甲基橄榄素B(远杀菌素B-1)与脱氧- o -甲基橄榄素C结构差异对生物活性的影响。
Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity.
Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methylolivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.
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