[锂在大鼠红细胞中刺激钠外排的证明]。

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie Pub Date : 1983-01-01

M L Grichois, D Franck, M De Mendonca

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引用次数: 0

摘要

在人红细胞中，细胞外Na+与细胞内Na+以一比一的比例交换。该系统的功能尚不清楚，但其活性在某些高血压或躁狂抑郁症中发生改变。它的活性可以通过测量细胞外介质(锂、瓦巴因和布美他尼)中Na+通量的速率来确定。它受到根皮素的抑制。在这项工作中，在大鼠红细胞中也发现了类似的通量。

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[Demonstration of a sodium efflux stimulated by lithium in rat erythrocytes].

A system exchanging extracellular Na+ against intracellular Na+ in a one to one ratio has been characterized in human erythrocyte. The function of this system is not yet shown, however its activity is altered in some hypertensive or manic depressives. Its activity can be determined by measuring the rate of Na+ flux in the presence in the extracellular medium, of lithium, ouabain and bumetanide. It is inhibited by phloretin. In this work, a similar flux has been demonstrated in Rat erythrocyte.

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Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie

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