[阿霉素对人体外溶血的血清增强作用]。

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie Pub Date : 1983-01-10

J Y Follézou, M Bizon, J Gicquel

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引用次数: 0

摘要

研究了阿霉素在磷酸介质pH7和人血清中对人红细胞的溶解作用。药物引起的溶血，其浓度明显高于治疗中所见的血浆水平，在血清中被强烈增强。这是第一个通过人血清因子调节阿霉素生物作用的关系。

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[Serum potentiation of hemolysis induced in vitro by adriamycin in man].

Human red cells lysis produced by adriamycin in vitro was investigated both in phosphate medium pH7 and in human serum. Drug induced hemolysis, that appeared with concentrations markedly above plasmatic levels seen in therapeutic, was stongly enhanced by serum. It is the first relations of modulation through a human serum factor of a biological action of adriamycin.

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Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie

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