大剂量1-(4-氨基-2-甲基-5-嘧啶基)-甲基-3-(2-氯乙基)-3-硝基盐酸索雷(ACNU)联合自体骨髓抢救脑干肿瘤患者。

Child's brain Pub Date : 1984-01-01 DOI:10.1159/000120200

T Hara, S Miyazaki, E Ishii, N Yoshida, K Inaba, K Ikeda, N Goya

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引用次数: 7

摘要

采用自体骨髓抢救高剂量ACNU治疗脑干肿瘤4例。血液学和非血液学毒性不深。有客观证据表明，4人中有2人有反应。所有患者均存活11-21个月。大剂量ACNU与骨髓抢救的安全管理需要进一步的对照研究，以确定其优于常规剂量。

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High-dose 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitro sou rea hydrochloride (ACNU) with autologous bone marrow rescue for patients with brain stem tumors.

4 patients with brain stem tumors were treated with high-dose ACNU with autologous bone marrow rescue. Hematologic and nonhematologic toxicities were not profound. There was objective evidence of response in 2 out of the 4. All were alive for 11-21 months from onset. Safe administration of high-dose ACNU with marrow rescue will warrant further control studies to determine its superiority over conventional doses.

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Child's brain

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