兔链球菌感染后实验性肾小球肾炎。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-08-01

A M Bergholm, S E Holm

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引用次数: 0

摘要

将活群A、M56链球菌接种于家兔皮下植入的钢网箱中，建立局部感染。通过定量测定笼液中细菌的数量来监测感染过程。肾脏病变的功能体征通过尿液分析和血清肌酐测定。所有动物在接种后2-8周处死，出现肾脏病变的组织学和免疫学征象。观察到的形态学和功能异常与人类链球菌感染后肾小球肾炎非常相似。

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Experimental poststreptococcal glomerulonephritis in rabbits.

Viable group A, M56 streptococci were inoculated into subcutaneously implanted steel net cages in rabbits, thereby establishing a local infection. The infectious process was monitored by quantitating the number of bacteria in the cage fluids. Functional signs of renal lesion were followed by urine analysis and measurement of serum creatinine. All animals were sacrificed 2-8 weeks after the inoculation and showed histological and immunological signs of kidney lesions. The morphological and functional abnormalities observed closely mimic those of post-streptococcal glomerulonephritis in man.

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Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology

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