{"title":"蛋氨酸脑啡肽fk33 -824合成类似物对抑郁症状的急性影响","authors":"G Jungkunz, N Nedopil, E Rüther","doi":"10.1055/s-2007-1017456","DOIUrl":null,"url":null,"abstract":"<p><p>Nine patients with endogenous depression have been treated with infusions of the synthetic methionine enkephaline analogue FK 33-824 for two days. Only on the first day acute effects on depressive symptoms could be observed. It cannot be decided if the observed mood alterations on the first treatment day are placebo effects. Depressive patients showed fewer adverse reactions than healthy volunteers. This might be explained by the previously described greater pain tolerance in depressives.</p>","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"16 3","pages":"90-2"},"PeriodicalIF":0.0000,"publicationDate":"1983-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1017456","citationCount":"11","resultStr":"{\"title\":\"Acute effects of the synthetic analogue of methionine enkephalin FK 33-824 on depressive symptoms.\",\"authors\":\"G Jungkunz, N Nedopil, E Rüther\",\"doi\":\"10.1055/s-2007-1017456\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Nine patients with endogenous depression have been treated with infusions of the synthetic methionine enkephaline analogue FK 33-824 for two days. Only on the first day acute effects on depressive symptoms could be observed. It cannot be decided if the observed mood alterations on the first treatment day are placebo effects. Depressive patients showed fewer adverse reactions than healthy volunteers. This might be explained by the previously described greater pain tolerance in depressives.</p>\",\"PeriodicalId\":19840,\"journal\":{\"name\":\"Pharmacopsychiatria\",\"volume\":\"16 3\",\"pages\":\"90-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1055/s-2007-1017456\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacopsychiatria\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-2007-1017456\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacopsychiatria","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-2007-1017456","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Acute effects of the synthetic analogue of methionine enkephalin FK 33-824 on depressive symptoms.
Nine patients with endogenous depression have been treated with infusions of the synthetic methionine enkephaline analogue FK 33-824 for two days. Only on the first day acute effects on depressive symptoms could be observed. It cannot be decided if the observed mood alterations on the first treatment day are placebo effects. Depressive patients showed fewer adverse reactions than healthy volunteers. This might be explained by the previously described greater pain tolerance in depressives.
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