小鼠黑色素瘤中分离的过氧化物酶氧化酪氨酸生成多巴胺。

Physiological chemistry and physics Pub Date : 1982-01-01
M R Okun, L Schley, R Ziegelstein, H Blair
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引用次数: 0

摘要

从B16小鼠黑色素瘤中分离出的过氧化物酶,在多巴或富马酸二羟基辅助因子存在的情况下将酪氨酸转化为多巴胺。克隆培养的B16小鼠黑色素瘤细胞悬浮匀浆也显示,在富马酸二羟基辅助因子存在下,酪氨酸向多巴胺的过氧化物转化。这些发现证实了先前的组织化学、放射自显影组织化学和电磁组织化学研究表明,黑色素瘤过氧化物酶可以将酪氨酸转化为黑色素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidation of tyrosine to dopachrome by peroxidase isolated from murine melanoma.

Peroxidase, isolated from B16 mouse melanoma, converted tyrosine to dopachrome in the presence of either dopa or dihydroxyfumarate co-factor. A suspended homogenate of cloned, cultured B16 mouse melanoma cells also showed peroxidatic conversion of tyrosine to dopachrome in the presence of dihydroxyfumarate co-factor. The findings confirm previous histochemical, autoradiographic-histochemical, and EM-histochemical studies showing that melanoma peroxidase can convert tyrosine to melanin.

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