Jean-Paul Boissel , Henri Wajcman , Hubert Fabritius , Raymond Cabannes , Dominique Labie
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Application of high-performance liquid chromatography to abnormal hemoglobin studies
A strategy is reported which allows the rapid characterization of different hemoglobins D found in Ivory Coast. It involves reverse-phase HPLC for peptide separations and micro-sequencing by the manual solid-phase method of Chang. Identification of hemoglobin Avicenna, hemoglobin Korle Bu and hemoglobin Cocody, a new variant (β 21 (B3) Asp → Asn), is described.