{"title":"Nb兜帽大鼠肾母细胞瘤的发生、移植和组织学特征。","authors":"G C Hard, R L Noble","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Ten kidney tumors conforming to nephroblastoma were encountered during a 10-year period in a closed colony of Nb hooded rats. Histologic examination of the primary neoplasms, and of a limited number of transplanted derivatives, indicates that spontaneous nephroblastoma in the rat is exclusively an epithelial neoplasm, consisting of dense aggregates of undifferentiated, basophilic blast cells set in a connective tissue stroma of benign character. This uniform entity should be clearly distinguished from renal mesenchymal tumor, a connective tissue neoplasm of heterogeneous form which is induced frequently in rats by certain chemical carcinogens.</p>","PeriodicalId":14519,"journal":{"name":"Investigative urology","volume":"18 5","pages":"371-6"},"PeriodicalIF":0.0000,"publicationDate":"1981-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Occurrence, transplantation, and histologic characteristics of nephroblastoma in the Nb hooded rat.\",\"authors\":\"G C Hard, R L Noble\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ten kidney tumors conforming to nephroblastoma were encountered during a 10-year period in a closed colony of Nb hooded rats. Histologic examination of the primary neoplasms, and of a limited number of transplanted derivatives, indicates that spontaneous nephroblastoma in the rat is exclusively an epithelial neoplasm, consisting of dense aggregates of undifferentiated, basophilic blast cells set in a connective tissue stroma of benign character. This uniform entity should be clearly distinguished from renal mesenchymal tumor, a connective tissue neoplasm of heterogeneous form which is induced frequently in rats by certain chemical carcinogens.</p>\",\"PeriodicalId\":14519,\"journal\":{\"name\":\"Investigative urology\",\"volume\":\"18 5\",\"pages\":\"371-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Investigative urology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Investigative urology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Occurrence, transplantation, and histologic characteristics of nephroblastoma in the Nb hooded rat.
Ten kidney tumors conforming to nephroblastoma were encountered during a 10-year period in a closed colony of Nb hooded rats. Histologic examination of the primary neoplasms, and of a limited number of transplanted derivatives, indicates that spontaneous nephroblastoma in the rat is exclusively an epithelial neoplasm, consisting of dense aggregates of undifferentiated, basophilic blast cells set in a connective tissue stroma of benign character. This uniform entity should be clearly distinguished from renal mesenchymal tumor, a connective tissue neoplasm of heterogeneous form which is induced frequently in rats by certain chemical carcinogens.
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