[克罗恩病和溃疡性结肠炎酶活性增强(作者译)]。

Chirurgisches Forum fur experimentelle und klinische Forschung Pub Date : 1980-01-01

S von Bary, H Kortmann, E B Tremmel, U Seemüller

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摘要

1. 克罗恩溃疡性结肠炎肠组织样品中胶原溶解活性增强。2. 当使用特异性胶原酶抑制剂EDTA时，未发现对胶原溶解活性的抑制作用。2. 在体外，EGLIN B的应用导致胶原溶解明显减少。EGLIN是最近发现的丝氨酸蛋白酶(如Elastase)抑制剂。

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[Enhanced enzymatic activity of Crohn's disease and ulcerative colitis (author's transl)].

1. An enhanced collagenolytic activity in the bowel tissue samples of M. Crohn and ulcerative colitis is demonstrated. 2. No inhibition of the collagenolytic activity was found when the specific collagenase inhibitor EDTA was applied. 2. In vitro, the application of EGLIN B resulted in a significant decrease of collagenolysis. EGLIN is a recently detected inhibitor of serine proteases such as Elastase.

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Chirurgisches Forum fur experimentelle und klinische Forschung

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