{"title":"甲状腺功能减退对大鼠心肌收缩力及肌浆网功能的影响。","authors":"I E Takács, J Szabó, A J Szentmiklósi, J Szegi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Changes in contractility and ATPase activity of SR from hearts of hypothyroid rats were investigated. Rats were made hypothyroid by daily injection of 100 mg/kg methimazole for 14 days. In methimazole-treated rats, the contractile force, the maximum velocity of tension development and relaxation were significantly decreased, however, the time to peak tension remained unchanged. Function of SR was studied by determining of Ca2+-activated ATPase activity, which was significantly decreased after methimazole treatment. This diminution may be partially responsible for a slower reduction of the free Ca2+ in the surroundings of contractile proteins and thus decrease the rate of relaxation.</p>","PeriodicalId":7056,"journal":{"name":"Acta biologica Academiae Scientiarum Hungaricae","volume":"33 4","pages":"391-7"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of hypothyroidism on myocardial contractility and sarcoplasmic reticulum function in rats.\",\"authors\":\"I E Takács, J Szabó, A J Szentmiklósi, J Szegi\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Changes in contractility and ATPase activity of SR from hearts of hypothyroid rats were investigated. Rats were made hypothyroid by daily injection of 100 mg/kg methimazole for 14 days. In methimazole-treated rats, the contractile force, the maximum velocity of tension development and relaxation were significantly decreased, however, the time to peak tension remained unchanged. Function of SR was studied by determining of Ca2+-activated ATPase activity, which was significantly decreased after methimazole treatment. This diminution may be partially responsible for a slower reduction of the free Ca2+ in the surroundings of contractile proteins and thus decrease the rate of relaxation.</p>\",\"PeriodicalId\":7056,\"journal\":{\"name\":\"Acta biologica Academiae Scientiarum Hungaricae\",\"volume\":\"33 4\",\"pages\":\"391-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta biologica Academiae Scientiarum Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta biologica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of hypothyroidism on myocardial contractility and sarcoplasmic reticulum function in rats.
Changes in contractility and ATPase activity of SR from hearts of hypothyroid rats were investigated. Rats were made hypothyroid by daily injection of 100 mg/kg methimazole for 14 days. In methimazole-treated rats, the contractile force, the maximum velocity of tension development and relaxation were significantly decreased, however, the time to peak tension remained unchanged. Function of SR was studied by determining of Ca2+-activated ATPase activity, which was significantly decreased after methimazole treatment. This diminution may be partially responsible for a slower reduction of the free Ca2+ in the surroundings of contractile proteins and thus decrease the rate of relaxation.
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