[鞘内辣椒素和P物质对大鼠伤害阈值的急性影响]。

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie Pub Date : 1983-01-01

B Dib

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引用次数: 0

摘要

我们比较了单次鞘内注射辣椒素或P物质(SP)对大鼠对辐射热和电伤害性刺激的运动反应的影响。在痛觉性电刺激下，所有大鼠在辣椒素注射后立即出现痛觉过敏。另一方面，SP后部分大鼠表现为痛觉过敏，部分大鼠表现为痛觉减退。辣椒素和SP均可引起17只大鼠对辐射热的痛觉减退。5只大鼠无反应。

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[Acute effects of intrathecal capsaicin and substance P on nociceptive thresholds in rats].

We have compared the effects of a single intrathecal injection of capsaicin or substance P (SP) on the motor responses to radiant heat and electrical nociceptive stimulations in the Rat. With nociceptive electrical stimulation, an immediate hyperalgesia followed capsaicin injection in all Rats. On the other hand, some Rats displayed hyperalgesia after SP while others showed hypoalgesia. Both capsaicin and SP, induced hypoalgesia to radiant heat in 17 rats. In 5 rats no response was obtained.

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Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie

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