{"title":"O抗原对伤寒沙门氏菌感染的保护作用。","authors":"I Jaszovszky","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Mice were actively immunized with preparations produced from different Salmonella strains. They were challenged with 2 LD50 of a virulent S. typhi-murium strain and examined for viable cell counts in the liver 4, 7 and 11 days postinfection. Whole cell vaccines, ribosomal extracts and endotoxin preparations of the O antigen-deficient variant of S. typhi-murium strain LT2-MI failed to protect the mice or did so in a much lower degree than preparations of the corresponding O antigen-bearing variant. Preparations from other salmonellae exerted a protective action only if the strain had an O-antigen identical with that of S. typhi-murium. The results pointed to a considerable protective role of the O antigen.</p>","PeriodicalId":75387,"journal":{"name":"Acta microbiologica Academiae Scientiarum Hungaricae","volume":"29 2","pages":"105-13"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protective role of O antigen in Salmonella typhi-murium infection.\",\"authors\":\"I Jaszovszky\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Mice were actively immunized with preparations produced from different Salmonella strains. They were challenged with 2 LD50 of a virulent S. typhi-murium strain and examined for viable cell counts in the liver 4, 7 and 11 days postinfection. Whole cell vaccines, ribosomal extracts and endotoxin preparations of the O antigen-deficient variant of S. typhi-murium strain LT2-MI failed to protect the mice or did so in a much lower degree than preparations of the corresponding O antigen-bearing variant. Preparations from other salmonellae exerted a protective action only if the strain had an O-antigen identical with that of S. typhi-murium. The results pointed to a considerable protective role of the O antigen.</p>\",\"PeriodicalId\":75387,\"journal\":{\"name\":\"Acta microbiologica Academiae Scientiarum Hungaricae\",\"volume\":\"29 2\",\"pages\":\"105-13\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta microbiologica Academiae Scientiarum Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta microbiologica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Protective role of O antigen in Salmonella typhi-murium infection.
Mice were actively immunized with preparations produced from different Salmonella strains. They were challenged with 2 LD50 of a virulent S. typhi-murium strain and examined for viable cell counts in the liver 4, 7 and 11 days postinfection. Whole cell vaccines, ribosomal extracts and endotoxin preparations of the O antigen-deficient variant of S. typhi-murium strain LT2-MI failed to protect the mice or did so in a much lower degree than preparations of the corresponding O antigen-bearing variant. Preparations from other salmonellae exerted a protective action only if the strain had an O-antigen identical with that of S. typhi-murium. The results pointed to a considerable protective role of the O antigen.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
