{"title":"保利(5-methoxycytidylic酸)","authors":"Cho Fat Hui, David W. Hutchinson","doi":"10.1016/0005-2787(81)90077-0","DOIUrl":null,"url":null,"abstract":"<div><p>Poly(5-methoxycytidylic acid) [poly(mo<sup>5</sup>C)] has been prepared by polymerization of 5-methoxycytidine diphosphate with polynucleotide phosphorylase. The poly(mo<sup>5</sup>C) was of high molecular weight and formed a 1 : 1 hybrid with poly(I). Although the <span><math><mtext>T</mtext><msub><mi></mi><mn><mtext>m</mtext></mn></msub></math></span> of this hybrid is higher than that of poly(I) · poly(C) in 0.1 M salt, poly(I) · poly(mo<sup>5</sup>C) is not an inducer of interferon.</p></div>","PeriodicalId":100164,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis","volume":"656 2","pages":"Pages 129-133"},"PeriodicalIF":0.0000,"publicationDate":"1981-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0005-2787(81)90077-0","citationCount":"1","resultStr":"{\"title\":\"Poly(5-methoxycytidylic acid)\",\"authors\":\"Cho Fat Hui, David W. Hutchinson\",\"doi\":\"10.1016/0005-2787(81)90077-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Poly(5-methoxycytidylic acid) [poly(mo<sup>5</sup>C)] has been prepared by polymerization of 5-methoxycytidine diphosphate with polynucleotide phosphorylase. The poly(mo<sup>5</sup>C) was of high molecular weight and formed a 1 : 1 hybrid with poly(I). Although the <span><math><mtext>T</mtext><msub><mi></mi><mn><mtext>m</mtext></mn></msub></math></span> of this hybrid is higher than that of poly(I) · poly(C) in 0.1 M salt, poly(I) · poly(mo<sup>5</sup>C) is not an inducer of interferon.</p></div>\",\"PeriodicalId\":100164,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis\",\"volume\":\"656 2\",\"pages\":\"Pages 129-133\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0005-2787(81)90077-0\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0005278781900770\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0005278781900770","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Poly(5-methoxycytidylic acid) [poly(mo5C)] has been prepared by polymerization of 5-methoxycytidine diphosphate with polynucleotide phosphorylase. The poly(mo5C) was of high molecular weight and formed a 1 : 1 hybrid with poly(I). Although the of this hybrid is higher than that of poly(I) · poly(C) in 0.1 M salt, poly(I) · poly(mo5C) is not an inducer of interferon.
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