{"title":"精神分裂症患者和健康对照中的谷氨酸","authors":"W F Gattaz, D Gattaz, H Beckmann","doi":"10.1007/BF00343292","DOIUrl":null,"url":null,"abstract":"<p><p>Cerebrospinal fluid (CSF) glutamate levels were measured in 28 paranoid schizophrenic patients and 15 healthy individuals. From the 28 patients 15 were treated with neuroleptic drugs and 13 did not take any drugs. No significant difference was found between glutamate in patients without neuroleptics and controls. However, CSF glutamate was significantly higher in patients taking neuroleptics than in controls (P less than 0.001) or in patients without neuroleptics (P less than 0.01). This and other data from the literature indicate that enhanced levels of cerebral glutamate may be significant for the antipsychotic efficacy of neuroleptic drugs.</p>","PeriodicalId":55482,"journal":{"name":"Archiv Fur Psychiatrie Und Nervenkrankheiten","volume":"231 3","pages":"221-5"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00343292","citationCount":"28","resultStr":"{\"title\":\"Glutamate in schizophrenics and healthy controls.\",\"authors\":\"W F Gattaz, D Gattaz, H Beckmann\",\"doi\":\"10.1007/BF00343292\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cerebrospinal fluid (CSF) glutamate levels were measured in 28 paranoid schizophrenic patients and 15 healthy individuals. From the 28 patients 15 were treated with neuroleptic drugs and 13 did not take any drugs. No significant difference was found between glutamate in patients without neuroleptics and controls. However, CSF glutamate was significantly higher in patients taking neuroleptics than in controls (P less than 0.001) or in patients without neuroleptics (P less than 0.01). This and other data from the literature indicate that enhanced levels of cerebral glutamate may be significant for the antipsychotic efficacy of neuroleptic drugs.</p>\",\"PeriodicalId\":55482,\"journal\":{\"name\":\"Archiv Fur Psychiatrie Und Nervenkrankheiten\",\"volume\":\"231 3\",\"pages\":\"221-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF00343292\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archiv Fur Psychiatrie Und Nervenkrankheiten\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF00343292\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archiv Fur Psychiatrie Und Nervenkrankheiten","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF00343292","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cerebrospinal fluid (CSF) glutamate levels were measured in 28 paranoid schizophrenic patients and 15 healthy individuals. From the 28 patients 15 were treated with neuroleptic drugs and 13 did not take any drugs. No significant difference was found between glutamate in patients without neuroleptics and controls. However, CSF glutamate was significantly higher in patients taking neuroleptics than in controls (P less than 0.001) or in patients without neuroleptics (P less than 0.01). This and other data from the literature indicate that enhanced levels of cerebral glutamate may be significant for the antipsychotic efficacy of neuroleptic drugs.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
