氯丙嗪对偶联质粒转移及性毛的影响。

Y Mándi, J Molnár
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引用次数: 0

摘要

主要镇静剂氯丙嗪(Cpz)抑制R和F'lac质粒的偶联转移。在50-100微克/毫升浓度的Cpz作用下,R-144和R-100质粒的转移频率降低了2-3 log,而在相同条件下,RM-98质粒的转移频率没有变化。Cpz浓度为100微克/毫升时,能有效抑制F'lac质粒的转移。电镜和菌斑分析显示,100微克/毫升Cpz可降低雄性特异性核糖核酸噬菌体MS-2对毛毛侧壁的吸附率。普通毛和鞭毛似乎是完整的,但性毛可能在Cpz存在时退缩。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of chlorpromazine on conjugal plasmid transfer and sex pili.

The major tranquillizer chlorpromazine (Cpz) inhibited the conjugal transfer of R and F'lac plasmids. The frequency of transfer of R-144 and R-100 plasmids was reduced with 2-3 log by Cpz at a concentration of 50-100 microgram/ml, while the frequency of RM-98 plasmid did not change under the same conditions. Cpz at 100 microgram/ml was an effective inhibitor of the transfer of F'lac plasmid. By means of electron microscopy and plaque assay, 100 microgram/ml Cpz was shown to reduce the adsorption rate of male specific ribonucleic acid phages MS-2 to the sides of F-pili. Common pili and flagellae seemed to be intact, but sex pili probably retracted in the presence of Cpz.

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