功能性阿片活性根据酒精滥用的不同方式而变化。

Substance and alcohol actions/misuse Pub Date : 1984-01-01
F Facchinetti, F Petraglia, G Nappi, E Martignoni, E Sinforiani, G Bono, A R Genazzani
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引用次数: 0

摘要

两组酒精依赖者(共14名)接受传统手工针刺治疗,分别在基础状态和停针后1、5、20和60分钟测量垂体激素血浆水平,包括b -内啡肽(B-EP)。A组患者有消极情绪的极性,表现出焦虑的迹象,而B组则由所谓的“社交饮酒者”组成。A、b组血浆ACTH、皮质醇、催乳素和生长激素水平对TMA均无显著反应。社交饮酒者对TMA反应后血浆B-EP水平升高(128 +/- 62.1%,平均+/- SD),而焦虑性酗酒者则无明显变化(2.8 +/- 38.6%,p < 0.01)。b -促脂蛋白血浆水平也是如此。这些初步结果表明,不同的酒精滥用模式可能与内源性阿片系统的不同反应性有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional opioid activity variates according to the different fashion of alcohol abuse.

Two groups of alcohol addicts (total of 14 subjects), were submitted to Traditional Manual Acupuncture and pituitary hormone plasma levels, including B-Endorphin (B-EP), were measured in basal condition and after 1, 5, 20 and 60 minutes from needle withdrawal. Group A patients had a polarity towards negative affective tone presenting signs of dysphoria while group B was composed of the so-called "social drinkers". No difference existed in basal hormonal values, except slightly elevated plasma B-EP levels in group A. No significant responses to TMA were recorded in plasma ACTH, Cortisol, Prolactin or GH levels in groups A and B. Social drinkers showed an increase of B-EP plasma levels in response to TMA (128 +/- 62.1%, mean +/- SD) which on the contrary was absent in dysphoric alcoholics (2.8 +/- 38.6%, p less than 0.01). The same was true for B-Lipotropin plasma levels. These preliminary results suggest that different fashions of alcohol abuse may be associated with different reactivity of the endogenous opioid system.

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