{"title":"新型精神镇静药物HS-2314的实验研究","authors":"G. Sierra, C. Acuna, J. Otero, G. Docampo","doi":"10.1016/0028-3908(69)90008-2","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of HS-2314, a new psychosedative drug, was determined in unanesthetized, unrestrained cats and rabbits. The effect was measured by the use of several electro-physiological techniques and behavioural observations. A comparative study with chlordiazepoxide, diazepam and chlorpromazine was performed.</p><p>It was found that HS-2314 reduced aggressiveness in cats, abolished the amygdala spindles induced by presentation of a rat and evoked synchronization of the EEG in several cortical and subcortical structures. HS-2314 seems to be clearly differentiated from diazepam, chlordiazepoxide and chlorpromazine.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 2","pages":"Pages 153-160, IN8"},"PeriodicalIF":0.0000,"publicationDate":"1969-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90008-2","citationCount":"3","resultStr":"{\"title\":\"Experimental study of a new psychosedative drug: HS-2314\",\"authors\":\"G. Sierra, C. Acuna, J. Otero, G. Docampo\",\"doi\":\"10.1016/0028-3908(69)90008-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effect of HS-2314, a new psychosedative drug, was determined in unanesthetized, unrestrained cats and rabbits. The effect was measured by the use of several electro-physiological techniques and behavioural observations. A comparative study with chlordiazepoxide, diazepam and chlorpromazine was performed.</p><p>It was found that HS-2314 reduced aggressiveness in cats, abolished the amygdala spindles induced by presentation of a rat and evoked synchronization of the EEG in several cortical and subcortical structures. HS-2314 seems to be clearly differentiated from diazepam, chlordiazepoxide and chlorpromazine.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":\"8 2\",\"pages\":\"Pages 153-160, IN8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90008-2\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390869900082\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Experimental study of a new psychosedative drug: HS-2314
The effect of HS-2314, a new psychosedative drug, was determined in unanesthetized, unrestrained cats and rabbits. The effect was measured by the use of several electro-physiological techniques and behavioural observations. A comparative study with chlordiazepoxide, diazepam and chlorpromazine was performed.
It was found that HS-2314 reduced aggressiveness in cats, abolished the amygdala spindles induced by presentation of a rat and evoked synchronization of the EEG in several cortical and subcortical structures. HS-2314 seems to be clearly differentiated from diazepam, chlordiazepoxide and chlorpromazine.
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