{"title":"丁苯那嗪对吗啡耐受的抑制作用及多巴对吗啡耐受的逆转作用","authors":"H. Takagi, H. Kuriki","doi":"10.1016/0028-3908(69)90014-8","DOIUrl":null,"url":null,"abstract":"<div><p>When repeated daily administrations of tetrabenazine were given 2 hr before daily injection of morphine in mice, the development of tolerance to morphine analgesia was markedly suppressed. This suppressive effect was antagonized by repeated administrations of DOPA. These findings suggest that catecholamines might be involved in the development of tolerance to morphine.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1969-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90014-8","citationCount":"19","resultStr":"{\"title\":\"Suppressive effect of tetrabenazine on the development of tolerance to morphine and its reversal by DOPA\",\"authors\":\"H. Takagi, H. Kuriki\",\"doi\":\"10.1016/0028-3908(69)90014-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>When repeated daily administrations of tetrabenazine were given 2 hr before daily injection of morphine in mice, the development of tolerance to morphine analgesia was markedly suppressed. This suppressive effect was antagonized by repeated administrations of DOPA. These findings suggest that catecholamines might be involved in the development of tolerance to morphine.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90014-8\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390869900148\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900148","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Suppressive effect of tetrabenazine on the development of tolerance to morphine and its reversal by DOPA
When repeated daily administrations of tetrabenazine were given 2 hr before daily injection of morphine in mice, the development of tolerance to morphine analgesia was markedly suppressed. This suppressive effect was antagonized by repeated administrations of DOPA. These findings suggest that catecholamines might be involved in the development of tolerance to morphine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
