{"title":"氯丙嗪和d-安非他明混合物对自发行为的影响","authors":"M.I. Phillips , P.B. Bradley","doi":"10.1016/0028-3908(69)90010-0","DOIUrl":null,"url":null,"abstract":"<div><p>In two tests of spontaneous activity, rats given d-amphetamine in doses of 1.0, 2.0 and 4.0 mg/kg became hyperactive. Chlorpromazine in doses of 0.5 and 1.0 mg/kg blocked this hyperactivity by increasing the periods of immobility, ambulation and grooming, as measured in an observation box and increasing the number of alleys entered in a Y-maze. In addition, the phenothiazine reduced head lifting, sniffing, head turning and rearing, which appeared in amphetamine treated rats. The most pronounced counter-effects on behaviour induced by 4 mg/kg d-amphetamine, were brought about by 1.0 mg/kg chlorpromazine, but the same ratio of 4: 1 at half these doses was less effective. The possible source of this behavioural antagonism of the two drugs, at a neuronal and a non-neuronal level, is discussed.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1969-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90010-0","citationCount":"10","resultStr":"{\"title\":\"The effect of chlorpromazine and d-amphetamine mixtures on spontaneous behaviour\",\"authors\":\"M.I. Phillips , P.B. Bradley\",\"doi\":\"10.1016/0028-3908(69)90010-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In two tests of spontaneous activity, rats given d-amphetamine in doses of 1.0, 2.0 and 4.0 mg/kg became hyperactive. Chlorpromazine in doses of 0.5 and 1.0 mg/kg blocked this hyperactivity by increasing the periods of immobility, ambulation and grooming, as measured in an observation box and increasing the number of alleys entered in a Y-maze. In addition, the phenothiazine reduced head lifting, sniffing, head turning and rearing, which appeared in amphetamine treated rats. The most pronounced counter-effects on behaviour induced by 4 mg/kg d-amphetamine, were brought about by 1.0 mg/kg chlorpromazine, but the same ratio of 4: 1 at half these doses was less effective. The possible source of this behavioural antagonism of the two drugs, at a neuronal and a non-neuronal level, is discussed.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90010-0\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390869900100\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900100","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of chlorpromazine and d-amphetamine mixtures on spontaneous behaviour
In two tests of spontaneous activity, rats given d-amphetamine in doses of 1.0, 2.0 and 4.0 mg/kg became hyperactive. Chlorpromazine in doses of 0.5 and 1.0 mg/kg blocked this hyperactivity by increasing the periods of immobility, ambulation and grooming, as measured in an observation box and increasing the number of alleys entered in a Y-maze. In addition, the phenothiazine reduced head lifting, sniffing, head turning and rearing, which appeared in amphetamine treated rats. The most pronounced counter-effects on behaviour induced by 4 mg/kg d-amphetamine, were brought about by 1.0 mg/kg chlorpromazine, but the same ratio of 4: 1 at half these doses was less effective. The possible source of this behavioural antagonism of the two drugs, at a neuronal and a non-neuronal level, is discussed.