{"title":"通过同位素掺入亚细胞组分研究了氧tremorine对中枢神经系统蛋白质代谢的影响","authors":"L.J. Embree , J. Sjöstrand","doi":"10.1016/0028-3908(69)90007-0","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of oxotremorine upon the incorporation of<sup>3</sup>H-leucine into subcellular fractions has been investigated in two regions of the rat CNS, and a significant increase in protein synthesis has been demonstrated during the acute phase of oxotremorine-induced functional activity. The tissue concentration of free labelled amino acids was slightly decreased at this time thus eliminating an alteration in the free amino acid pool as a possible causative factor. There was no increase of isotope incorporation into liver proteins during the same period.</p><p>Repeated stimulation with this powerful tremorogenic drug did not change the turnover of proteins in the striatum or in the gray matter of the spinal cord.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 2","pages":"Pages 143-151"},"PeriodicalIF":0.0000,"publicationDate":"1969-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90007-0","citationCount":"1","resultStr":"{\"title\":\"The effect of oxotremorine on protein metabolism in the central nervous system studied by isotope incorporation into subcellular fractions\",\"authors\":\"L.J. Embree , J. Sjöstrand\",\"doi\":\"10.1016/0028-3908(69)90007-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effect of oxotremorine upon the incorporation of<sup>3</sup>H-leucine into subcellular fractions has been investigated in two regions of the rat CNS, and a significant increase in protein synthesis has been demonstrated during the acute phase of oxotremorine-induced functional activity. The tissue concentration of free labelled amino acids was slightly decreased at this time thus eliminating an alteration in the free amino acid pool as a possible causative factor. There was no increase of isotope incorporation into liver proteins during the same period.</p><p>Repeated stimulation with this powerful tremorogenic drug did not change the turnover of proteins in the striatum or in the gray matter of the spinal cord.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":\"8 2\",\"pages\":\"Pages 143-151\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90007-0\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390869900070\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900070","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of oxotremorine on protein metabolism in the central nervous system studied by isotope incorporation into subcellular fractions
The effect of oxotremorine upon the incorporation of3H-leucine into subcellular fractions has been investigated in two regions of the rat CNS, and a significant increase in protein synthesis has been demonstrated during the acute phase of oxotremorine-induced functional activity. The tissue concentration of free labelled amino acids was slightly decreased at this time thus eliminating an alteration in the free amino acid pool as a possible causative factor. There was no increase of isotope incorporation into liver proteins during the same period.
Repeated stimulation with this powerful tremorogenic drug did not change the turnover of proteins in the striatum or in the gray matter of the spinal cord.
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