直肠抽吸活检中乙酰胆碱酯酶活性对巨结肠病的诊断价值

IF 2.4 2区医学 Q1 PEDIATRICS

Journal of pediatric surgery Pub Date : 1972-02-01 DOI:10.1016/0022-3468(72)90394-6

W. Meier-Ruge M.D. , P.M. Lutterbeck M.D. , B. Herzog M.D. , R. Morger M.D. , R. Moser M.D. , A. Schärli M.D.

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引用次数: 240

摘要

直肠抽吸活检对214例怀疑患有巨结肠病的患者进行了直肠抽吸活检。通过常规组织学和乙酰胆碱酯酶(AChE)检测，66例(31%)被诊断为先天性巨结肠病，所有病例均经手术证实。通过专门评估乙酰胆碱酯酶活性，避免了活检材料不满意的问题。尽管在直肠最低3cm处神经节细胞正常缺乏，但Hirschsprung病的酶过度积累特征与典型的神经节节段变窄的结果相似。

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Acetylcholinesterase activity in suction biopsies of the rectum in the diagnosis of Hirschsprung's disease

Rectal suction biopsies have been employed in 214 subjects suspected of having Hirschsprung's disease. By applying conventional histology and acetylcholinesterase (AChE) determinations, 66 (31%) cases were diagnosed as Hirschsprung's disease—all of which were surgically confirmed. The problem of unsatisfactory biopsy material was circumvented by exclusively assessing for AChE activity. Despite the normal paucity of ganglion cells within the lowest 3 cm of the rectum, excessive enzyme accumulation characteristic of Hirschsprung's disease paralleled the findings obtained from the classical narrowed aganglionic segment.

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来源期刊

Journal of pediatric surgery 医学-外科

CiteScore

1.10

自引率

12.50%

发文量

569

审稿时长

38 days

期刊介绍： The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery. The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, pathology and surgical techniques, but also by attention to the unique emotional and physical needs of the young patient.