{"title":"垂体和尿肽诱导小鼠空腹低血糖和高胰岛素血症","authors":"Merlyn C. Minick","doi":"10.1016/0010-406X(70)90955-2","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. A urinary polypeptide (FI) from the urine of lipoatrophic diabetics and a similar peptide (BPI) from bovine adenohypophysis induced significant fasting hypoglycemia and increased glucose tolerance in the mouse.</p></span></li><li><span>2.</span><span><p>2. The effects of FI and BPI on blood sugar levels were absent in mice pretreated with alloxan and <span>D</span>-mannoheptulose.</p></span></li><li><span>3.</span><span><p>3. Plasma immunoinsulin was significantly increased after FI and BPI administration and significantly decreased in mice pretreated with <span>D</span>-mannoheptulose.</p></span></li><li><span>4.</span><span><p>4. It was concluded that FI and BPI induction of fasting hypoglycemia and enhanced glucose tolerance is mediated by endogenous insulin release.</p></span></li></ul></div>","PeriodicalId":78189,"journal":{"name":"Comparative biochemistry and physiology","volume":"37 1","pages":"Pages 39-48"},"PeriodicalIF":0.0000,"publicationDate":"1970-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0010-406X(70)90955-2","citationCount":"8","resultStr":"{\"title\":\"Induction of fasting hypoglycemia and hyperinsulinemia in the mouse by pituitary and urinary peptides\",\"authors\":\"Merlyn C. Minick\",\"doi\":\"10.1016/0010-406X(70)90955-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. A urinary polypeptide (FI) from the urine of lipoatrophic diabetics and a similar peptide (BPI) from bovine adenohypophysis induced significant fasting hypoglycemia and increased glucose tolerance in the mouse.</p></span></li><li><span>2.</span><span><p>2. The effects of FI and BPI on blood sugar levels were absent in mice pretreated with alloxan and <span>D</span>-mannoheptulose.</p></span></li><li><span>3.</span><span><p>3. Plasma immunoinsulin was significantly increased after FI and BPI administration and significantly decreased in mice pretreated with <span>D</span>-mannoheptulose.</p></span></li><li><span>4.</span><span><p>4. It was concluded that FI and BPI induction of fasting hypoglycemia and enhanced glucose tolerance is mediated by endogenous insulin release.</p></span></li></ul></div>\",\"PeriodicalId\":78189,\"journal\":{\"name\":\"Comparative biochemistry and physiology\",\"volume\":\"37 1\",\"pages\":\"Pages 39-48\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1970-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0010-406X(70)90955-2\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0010406X70909552\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0010406X70909552","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Induction of fasting hypoglycemia and hyperinsulinemia in the mouse by pituitary and urinary peptides
1.
1. A urinary polypeptide (FI) from the urine of lipoatrophic diabetics and a similar peptide (BPI) from bovine adenohypophysis induced significant fasting hypoglycemia and increased glucose tolerance in the mouse.
2.
2. The effects of FI and BPI on blood sugar levels were absent in mice pretreated with alloxan and D-mannoheptulose.
3.
3. Plasma immunoinsulin was significantly increased after FI and BPI administration and significantly decreased in mice pretreated with D-mannoheptulose.
4.
4. It was concluded that FI and BPI induction of fasting hypoglycemia and enhanced glucose tolerance is mediated by endogenous insulin release.
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