肾移植排斥反应中白细胞介素II的产生增加。

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

H Vie, M Bonneville, R Cariou, J F Moreau, J P Soulillou

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摘要

我们研究了从肾移植受体获得的外周血白细胞(PBL)凝集素诱导的白细胞介素II (IL-2)的产生。移植前值(血液透析患者)与健康人相似。移植后和第一年，功能良好的移植物受体的PBL产生的IL-2水平非常低(p < 0.001)。嫁接数年后，IL-2产量趋于恢复。在急性排斥反应开始时，IL-2的产生显著上升。这些数据表明，IL-2产生的增加可能在排斥过程中起作用。

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Increased interleukin II production during kidney allograft rejection.

We have studied the lectin-induced production of Interleukin II (IL-2) by peripheral blood leucocytes (PBL) obtained from recipients of kidney grafts. Pre-graft values (haemodialysed patients) are similar to those of healthy individuals. After grafting and during the first year the IL-2 levels produced by PBL from recipients with well functioning grafts are very low (p less than 0.001). Years after grafting the IL-2 yields tend towards restoration. At the onset of an acute rejection the IL-2 production rises significantly. These data show that an increase in IL-2 production may play a role in the rejection process.

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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