正常受试者的叶酸分解代谢。

Human nutrition. Applied nutrition Pub Date : 1987-10-01
H McNulty, J M McPartlin, D G Weir, J M Scott
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引用次数: 0

摘要

所有官方建议的叶酸摄入量往往远远超过目前的估计摄入量。最近的几项研究强调了这一点,表明健康人群的叶酸水平令人满意,摄入量远低于官方的每日推荐摄入量。这项研究对目前叶酸的rda进行了批判性的审视。我们最近开发了一种定量测定人体尿液中叶酸分解代谢的最终产物的方法,从而提供了一种更合理和科学的方法来设定叶酸的RDA。这项研究的结果(现已得到进一步工作的证实)表明,在正常的饮食条件下,身体似乎每天只分解约100微克的叶酸。此外,这种分解代谢率在连续数天服用饱和剂量的5毫克叶酸补充剂后保持相对不变。因此,我们的饮食不太可能像目前官方rda所暗示的那样严重缺乏叶酸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Folate catabolism in normal subjects.

All official recommendations for folate tend to be far in excess of current estimated intakes. Several recent studies have highlighted this, showing satisfactory folate status in healthy populations consuming considerably less than official RDAs. This study takes a critical look at current RDAs for folate. We have recently developed an assay to quantify the end product of folate catabolism in human urine, thus affording the possibility of a more rational and scientific approach to setting the RDA for folate. Results of this study (now confirmed by further work) suggest that, under normal dietary conditions, the body appears to catabolize only about 100 micrograms total folate per day. Furthermore, this rate of catabolism remained relatively unchanged in response to saturating doses of a 5 mg folic acid supplement over several days. It is therefore most unlikely that our diet is as seriously deficient in folate as current official RDAs seem to imply.

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