鸟分枝杆菌中选定抗菌药物的摄取。

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology Pub Date : 1987-07-01

H L David, S Clavel-Seres, F Clement, K S Goh

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引用次数: 0

摘要

在Middlebrook 7H9液体培养基中筛选64种药物对鸟分枝杆菌ATCC 15769的抑菌作用。活性最强的药物为安霉素、利福平、氯法齐明和普司他霉素。临床分离菌株在Middlebrook 7H10琼脂培养基上进行抑菌试验，证实了所选药物的抑菌作用。抗菌作用与药物的疏水性和分子量无关。然而，所有的活性药物都是低极性的高度疏水分子。这些药物溶解到脂质中，形成细菌包膜的外层，它们似乎与表面的两亲分子相互作用。

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Uptake of selected antibacterial agents in Mycobacterium avium.

The antibacterial action of 64 drugs against Mycobacterium avium ATCC 15769 was screened in Middlebrook 7H9 liquid medium. The most active drugs were ansamycin, rifampicin, clofazimine, and pristinamycin. The antibacterial action of the selected drugs was confirmed by testing clinical isolates on Middlebrook 7H10 agar medium. The antibacterial actions were not related with the hydrophobicities and molecular weights of the drugs. However, all the active drugs were highly hydrophobic molecules of low polarity. These drugs dissolved into the lipids forming the outer layers of the bacterial envelope and they appeared to interact with the surface amphiphils.

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Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology

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