精确子宫mRNA治疗恢复着床和生育能力

IF 22 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Today Pub Date : 2026-06-01 Epub Date: 2026-03-05 DOI:10.1016/j.mattod.2026.103270

Jun Liao , Zhiqiang Lin , Chuang Liu

引用次数: 0

摘要

子宫内膜功能障碍是植入失败的主要原因，但基于蛋白质的局部治疗受到快速清除和全身暴露的限制。最近的一项研究利用植入窗口（WOI）实现整合素靶向信使RNA （mRNA）的递送，将子宫内膜转变为治疗蛋白的短暂来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Precision uterine mRNA therapy to Restore implantation and fertility

查看原文本刊更多论文

Precision uterine mRNA therapy to Restore implantation and fertility

Endometrial dysfunction is a major cause of implantation failure, yet protein-based local therapies are limited by rapid clearance and systemic exposure. A recent study exploits the window of implantation (WOI) to enable integrin-targeted messenger RNA (mRNA) delivery, turning the endometrium into a transient source of therapeutic proteins.

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来源期刊

Materials Today 工程技术-材料科学：综合

CiteScore

36.30

自引率

1.20%

发文量

237

审稿时长

23 days

期刊介绍： Materials Today is the leading journal in the Materials Today family, focusing on the latest and most impactful work in the materials science community. With a reputation for excellence in news and reviews, the journal has now expanded its coverage to include original research and aims to be at the forefront of the field. We welcome comprehensive articles, short communications, and review articles from established leaders in the rapidly evolving fields of materials science and related disciplines. We strive to provide authors with rigorous peer review, fast publication, and maximum exposure for their work. While we only accept the most significant manuscripts, our speedy evaluation process ensures that there are no unnecessary publication delays.