体内形成的血液成分与冠状血管的相互作用。

Federation proceedings Pub Date : 1987-01-01
B R Lucchesi, J K Mickelson, J W Homeister, C V Jackson
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引用次数: 0

摘要

人们对血小板、中性粒细胞和血管内皮之间的相互作用给予了相当大的关注。越来越多的人认识到各种血液元素在血栓形成和血管闭塞的过程中相互作用。此外,这些细胞之间的相互作用可导致血管活性物质的形成和释放,这些物质具有调节局部血流的潜力。这篇综述的重点是冠状动脉血管床和评估细胞-细胞相互作用,在正常生理条件下以及存在心肌损伤,可能导致冠状动脉血管阻力和心肌功能的改变。如果相关事件在人类疾病的临床状态中起作用,血液的循环元素可以作为治疗干预措施的目标,以调节心肌血流量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interaction of the formed elements of blood with the coronary vasculature in vivo.

Considerable attention is being given to the interactions that occur among blood platelets, neutrophils, and the vascular endothelium. There is an increasing awareness that the various blood elements interact in the process of thrombus formation and vascular occlusion. In addition, interactions among these cells can lead to the formation and release of vasoactive substances that have the potential to modulate regional blood flow. This review focuses on the coronary vascular bed and an assessment of how cell-cell interactions, under normal physiological conditions as well as in the presence of myocardial injury, may lead to alterations in coronary vascular resistance and myocardial function. Should related events be operative in human clinical states of disease, the circulating elements of the blood may serve as targets in the development of therapeutic interventions to regulate myocardial blood flow.

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