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引用次数: 0
摘要
本文综述了全基因组关联研究（Genome Wide Association Studies， GWAS）的背景和实践方面。我介绍了几个实际使用的软件，以便读者可以轻松地执行GWAS。并对计算方法进行了说明。最后，对诸如遗传缺失或影响调控机制的基因间关联信号等高级主题提出了一些意见。
[Genome Wide Association Study:its theory and methodological review].
This review article describes the background and practical aspects for the Genome Wide Association Studies(GWAS). I introduce several softwares which are actually used in practice so that the readers could perform GWAS without difficulty. Imputation method is also explained. Finally, some comments are provided regarding advanced topics such as missing heritability or intergenic association signals affecting regulatory mechanisms.
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