{"title":"视神经脊髓炎模拟多发性硬化症:1例报告及文献综述。","authors":"Sunil Thatal, Susmin Karki, Asmita Parajuli, Sweta Bhandari, Bibek K. C., Dibasha Adhikari, Navin Kumar Sah","doi":"10.1002/ccr3.71277","DOIUrl":null,"url":null,"abstract":"<p>Neuromyelitis optica spectrum disorder (NMOSD) may mimic other neurological conditions, including multiple sclerosis (MS). We report a 25-year-old woman with hypothyroidism and depression who presented with progressive quadriparesis. Positive aquaporin-4 antibodies confirmed NMOSD. This case emphasizes the importance of considering NMOSD in patients with atypical demyelinating presentations and highlights the role of early diagnosis and targeted immunotherapy in improving outcomes.</p>","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"13 10","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521625/pdf/","citationCount":"0","resultStr":"{\"title\":\"Neuromyelitis Optica Mimicking Multiple Sclerosis: A Case Report and a Comprehensive Review of the Literature\",\"authors\":\"Sunil Thatal, Susmin Karki, Asmita Parajuli, Sweta Bhandari, Bibek K. C., Dibasha Adhikari, Navin Kumar Sah\",\"doi\":\"10.1002/ccr3.71277\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Neuromyelitis optica spectrum disorder (NMOSD) may mimic other neurological conditions, including multiple sclerosis (MS). We report a 25-year-old woman with hypothyroidism and depression who presented with progressive quadriparesis. Positive aquaporin-4 antibodies confirmed NMOSD. This case emphasizes the importance of considering NMOSD in patients with atypical demyelinating presentations and highlights the role of early diagnosis and targeted immunotherapy in improving outcomes.</p>\",\"PeriodicalId\":10327,\"journal\":{\"name\":\"Clinical Case Reports\",\"volume\":\"13 10\",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521625/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ccr3.71277\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ccr3.71277","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Neuromyelitis Optica Mimicking Multiple Sclerosis: A Case Report and a Comprehensive Review of the Literature
Neuromyelitis optica spectrum disorder (NMOSD) may mimic other neurological conditions, including multiple sclerosis (MS). We report a 25-year-old woman with hypothyroidism and depression who presented with progressive quadriparesis. Positive aquaporin-4 antibodies confirmed NMOSD. This case emphasizes the importance of considering NMOSD in patients with atypical demyelinating presentations and highlights the role of early diagnosis and targeted immunotherapy in improving outcomes.
期刊介绍:
Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).