缺氧和细胞骨架。

IF 4.4 2区 医学 Q1 NEUROSCIENCES
Darragh Flood, Cormac T Taylor
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引用次数: 0

摘要

高度调控和动态的细胞骨架对细胞生理功能和维持体内平衡至关重要。尽管我们对细胞骨架在生理条件下的调节机制了解甚多,但病理刺激的影响及其对疾病进展的影响仍知之甚少。缺氧是包括炎症、癌症和缺血在内的一系列病理状态的一个突出的微环境特征。在这篇综述中,我们总结了已知的缺氧对细胞骨架的影响,并讨论了这对生理和疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypoxia and the cytoskeleton.

A highly-regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis. Although much is known about the mechanisms by which the cytoskeleton is regulated under physiological conditions, the effect of pathological stimuli and how this contributes to disease progression remains poorly understood. Hypoxia is a prominent microenvironmental feature of a range of pathological states including inflammation, cancer and ischaemia. In this review, we summarise what is known about the effects of hypoxia on the cytoskeleton and discuss the implications of this for physiology and disease.

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来源期刊
Journal of Physiology-London
Journal of Physiology-London 医学-神经科学
CiteScore
9.70
自引率
7.30%
发文量
817
审稿时长
2 months
期刊介绍: The Journal of Physiology publishes full-length original Research Papers and Techniques for Physiology, which are short papers aimed at disseminating new techniques for physiological research. Articles solicited by the Editorial Board include Perspectives, Symposium Reports and Topical Reviews, which highlight areas of special physiological interest. CrossTalk articles are short editorial-style invited articles framing a debate between experts in the field on controversial topics. Letters to the Editor and Journal Club articles are also published. All categories of papers are subjected to peer reivew. The Journal of Physiology welcomes submitted research papers in all areas of physiology. Authors should present original work that illustrates new physiological principles or mechanisms. Papers on work at the molecular level, at the level of the cell membrane, single cells, tissues or organs and on systems physiology are all acceptable. Theoretical papers and papers that use computational models to further our understanding of physiological processes will be considered if based on experimentally derived data and if the hypothesis advanced is directly amenable to experimental testing. While emphasis is on human and mammalian physiology, work on lower vertebrate or invertebrate preparations may be suitable if it furthers the understanding of the functioning of other organisms including mammals.
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