{"title":"评估印度CML患者TNF α和IL-6水平及其与早期分子反应的相关性：一项观察性研究","authors":"Mohit Sahu, Sumita Chaudhry, Monica Sharma, Sumita Saluja, Aditi Jain, Ankur Jain","doi":"10.1007/s12288-024-01947-z","DOIUrl":null,"url":null,"abstract":"<p><p>The study aimed to study the correlation of inflammatory cytokines TNF α and IL6 with early molecular response (EMR) in Indian CML patients on Imatinib. Methods-A tertiary hospital based cross sectional observational study included 47 patients with newly diagnosed CML over a period of 18 months. Plasma levels of TNFα and IL6 along with levels of BCR-ABL were done at baseline and at 3 month of therapy. Results- TNFα at baseline was the better predictor of EMR not achieved at cut off point of > 109 pg/ml and IL6 at 3 month was the better predictor of EMR not achieved at cut off point of > 45 pg/ml Conclusion- The combination of high TNF and IL-6 levels at baseline and at 3 months identifies a high risk subset of CML patients with significantly lower EMR. Mesurement of these cytokines at above time points may allow treatment intensity to be individualised based on the patient's risk profile.</p>","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"836-842"},"PeriodicalIF":0.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515145/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessment of TNF α and IL-6 Levels in Indian Patients of CML and their Correlation with Early Molecular Response: An Observational Study.\",\"authors\":\"Mohit Sahu, Sumita Chaudhry, Monica Sharma, Sumita Saluja, Aditi Jain, Ankur Jain\",\"doi\":\"10.1007/s12288-024-01947-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The study aimed to study the correlation of inflammatory cytokines TNF α and IL6 with early molecular response (EMR) in Indian CML patients on Imatinib. Methods-A tertiary hospital based cross sectional observational study included 47 patients with newly diagnosed CML over a period of 18 months. Plasma levels of TNFα and IL6 along with levels of BCR-ABL were done at baseline and at 3 month of therapy. Results- TNFα at baseline was the better predictor of EMR not achieved at cut off point of > 109 pg/ml and IL6 at 3 month was the better predictor of EMR not achieved at cut off point of > 45 pg/ml Conclusion- The combination of high TNF and IL-6 levels at baseline and at 3 months identifies a high risk subset of CML patients with significantly lower EMR. Mesurement of these cytokines at above time points may allow treatment intensity to be individualised based on the patient's risk profile.</p>\",\"PeriodicalId\":49188,\"journal\":{\"name\":\"Indian Journal of Hematology and Blood Transfusion\",\"volume\":\"41 4\",\"pages\":\"836-842\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515145/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Hematology and Blood Transfusion\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12288-024-01947-z\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Hematology and Blood Transfusion","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12288-024-01947-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/11 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Assessment of TNF α and IL-6 Levels in Indian Patients of CML and their Correlation with Early Molecular Response: An Observational Study.
The study aimed to study the correlation of inflammatory cytokines TNF α and IL6 with early molecular response (EMR) in Indian CML patients on Imatinib. Methods-A tertiary hospital based cross sectional observational study included 47 patients with newly diagnosed CML over a period of 18 months. Plasma levels of TNFα and IL6 along with levels of BCR-ABL were done at baseline and at 3 month of therapy. Results- TNFα at baseline was the better predictor of EMR not achieved at cut off point of > 109 pg/ml and IL6 at 3 month was the better predictor of EMR not achieved at cut off point of > 45 pg/ml Conclusion- The combination of high TNF and IL-6 levels at baseline and at 3 months identifies a high risk subset of CML patients with significantly lower EMR. Mesurement of these cytokines at above time points may allow treatment intensity to be individualised based on the patient's risk profile.
期刊介绍：
Indian Journal of Hematology and Blood Transfusion is a medium for propagating and exchanging ideas within the medical community. It publishes peer-reviewed articles on a variety of aspects of clinical hematology, laboratory hematology and hemato-oncology. The journal exists to encourage scientific investigation in the study of blood in health and in disease; to promote and foster the exchange and diffusion of knowledge relating to blood and blood-forming tissues; and to provide a forum for discussion of hematological subjects on a national scale.
The Journal is the official publication of The Indian Society of Hematology & Blood Transfusion.
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