使用简单机械转染装置非病毒制造细胞免疫疗法（ad . therapp . 10/2025）

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Advanced Therapeutics Pub Date : 2025-10-14 DOI:10.1002/adtp.70061

Yerim Lee, Wanling Wong, Theresa Seah, Dionis Yew, Cyrus W. Beh

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引用次数: 0

摘要

被迫通过微孔的t细胞变得可渗透，让嵌合抗原受体（CAR） mRNA进入。这些细胞随后表达CAR蛋白，获得了强大的抗癌功能。这种方法为高效、可重复的制造提供了一条途径，并降低了患者的治疗成本。更多细节可以在Cyrus W. Beh及其同事的研究文章中找到（DOI: 2500094）。封面图片由Ahmad Amirul Abdul Rahim提供。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Non-Viral Manufacturing of Cellular Immunotherapy Using Simple Mechanical Transfection Device (Adv. Therap. 10/2025)

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Non-Viral Manufacturing of Cellular Immunotherapy Using Simple Mechanical Transfection Device (Adv. Therap. 10/2025)

T-cells forced through micro-sized pores become permeable, letting Chimeric Antigen Receptor (CAR) mRNA enter. The cells then express CAR proteins, gaining potent cancer-killing function. This method offers a path toward efficient, reproducible manufacturing and reduced therapy costs for patients. More details can be found in the Research Article by Cyrus W. Beh and co-workers (DOI: 2500094). Cover image by Ahmad Amirul Abdul Rahim.

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来源期刊

Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.10

自引率

2.20%

发文量

130