纳米酶在癌症诊断和治疗中的应用进展与展望

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-10-13 DOI:10.1021/acsami.5c10701

Ziqi Ding, Qi Sang, Yuning Wang, Kun Qian

{"title":"纳米酶在癌症诊断和治疗中的应用进展与展望","authors":"Ziqi Ding, Qi Sang, Yuning Wang, Kun Qian","doi":"10.1021/acsami.5c10701","DOIUrl":null,"url":null,"abstract":"Natural enzymes serve as indispensable biocatalysts in diverse biomedical applications. However, their clinical utility is constrained by poor stability and high purification costs. With the innovation of nanotechnology, various engineered nanomaterials with excellent catalytic activity exhibit the advantages in mimicking natural enzymes. By combining with advanced platforms, nanozymes have been widely used in the field of cancer diagnosis and treatment in recent years. In this review, we have systematically introduced the mechanisms and applications of nanozymes toward in vivo cancer diagnosis and treatment, as well as in vitro biomarker detection, alongside a comprehensive summary of their emerging application potential in cancer diagnosis and treatment.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"54 1","pages":""},"PeriodicalIF":8.2000,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advancement and Perspective of Nanozyme in Cancer Diagnosis and Treatment Applications\",\"authors\":\"Ziqi Ding, Qi Sang, Yuning Wang, Kun Qian\",\"doi\":\"10.1021/acsami.5c10701\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Natural enzymes serve as indispensable biocatalysts in diverse biomedical applications. However, their clinical utility is constrained by poor stability and high purification costs. With the innovation of nanotechnology, various engineered nanomaterials with excellent catalytic activity exhibit the advantages in mimicking natural enzymes. By combining with advanced platforms, nanozymes have been widely used in the field of cancer diagnosis and treatment in recent years. In this review, we have systematically introduced the mechanisms and applications of nanozymes toward in vivo cancer diagnosis and treatment, as well as in vitro biomarker detection, alongside a comprehensive summary of their emerging application potential in cancer diagnosis and treatment.\",\"PeriodicalId\":5,\"journal\":{\"name\":\"ACS Applied Materials & Interfaces\",\"volume\":\"54 1\",\"pages\":\"\"},\"PeriodicalIF\":8.2000,\"publicationDate\":\"2025-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Materials & Interfaces\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1021/acsami.5c10701\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acsami.5c10701","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

在各种生物医学应用中，天然酶是不可缺少的生物催化剂。然而，它们的临床应用受到稳定性差和纯化成本高的限制。随着纳米技术的创新，各种具有优异催化活性的工程纳米材料在模拟天然酶方面显示出优势。近年来，纳米酶与先进的平台相结合，在癌症诊断和治疗领域得到了广泛的应用。在本文中，我们系统地介绍了纳米酶在体内癌症诊断和治疗以及体外生物标志物检测中的作用机制和应用，并对其在癌症诊断和治疗中的应用潜力进行了全面的总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advancement and Perspective of Nanozyme in Cancer Diagnosis and Treatment Applications

查看原文本刊更多论文

Advancement and Perspective of Nanozyme in Cancer Diagnosis and Treatment Applications

Natural enzymes serve as indispensable biocatalysts in diverse biomedical applications. However, their clinical utility is constrained by poor stability and high purification costs. With the innovation of nanotechnology, various engineered nanomaterials with excellent catalytic activity exhibit the advantages in mimicking natural enzymes. By combining with advanced platforms, nanozymes have been widely used in the field of cancer diagnosis and treatment in recent years. In this review, we have systematically introduced the mechanisms and applications of nanozymes toward in vivo cancer diagnosis and treatment, as well as in vitro biomarker detection, alongside a comprehensive summary of their emerging application potential in cancer diagnosis and treatment.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.