从马龙果中分离出6种具有有效寨卡病毒抑制活性的香叶苷类黄酮衍生物。

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-10-08 DOI:10.1016/j.fitote.2025.106908

Jia-Bi Huang, Yong-Xiang Huang, Meng-Ru Wang, Guan-Rong Qiao, Shao-Zhong Luo, Wei-Lie Xiao, Chang-Bo Zheng, Xiao-Li Li

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引用次数: 0

摘要

从Macaranga denticulata m中分离得到6个未描述的香叶基类黄酮衍生物（1-6）和2个已知化合物（7-8）。参数。(家庭大戟科)。通过详细的光谱分析和文献资料对比，对其结构进行了表征。化合物4具有较强的寨卡病毒抑制活性，EC50值为8.72 μM。化合物4对Vero细胞具有较低的细胞毒性，CC50值大于100 μM。因此，化合物4有可能成为潜在的抗寨卡病毒制剂。

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Six undescribed geranylated flavonoid derivatives isolated from Macaranga denticulata with potent Zika virus inhibitory activity.

Six undescribed geranylated flavonoid derivatives (1-6), together with two known compounds (7-8), were isolated from Macaranga denticulata Müll. Arg. (family Euphorbiaceae). Their structures were characterized by detailed spectroscopic analysis and by comparison with literature data. Moreover, compound 4 exhibited potent Zika virus inhibitory activity, with EC₅₀ value of 8.72 μM. Compound 4 showed low cytotoxicity to Vero cells, with CC₅₀ value exceeding 100 μM. Hence, compound 4 may be developed as potential anti-ZIKV agents.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.